In-vitro investigation of coronary atherosclerosis on a modified vivitro system.
Tan, Rong Wang.
School/DeptSchool of Mechanical and Aeronautical Engineering
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Coronary heart disease (CHD) is a common cardiac disorder in which a portion of the coronary artery is blocked, leading to a potential heart attack. Timely and accurate evaluation of suspected CHD patients is critical. Computer Tomography Angiography (CTA) is used to scan and produce reports on the condition of a patient s coronary arteries, searching for stenosis (the narrowing of arteries) that precipitate CHD. Yet, the current diagnostic method used to interpret CTA results lack precision, requires expert input, and is often operator-dependent, resulting in significant numbers of further unnecessary tests and treatments. This method involves cardiologists eyeballing digital 3-dimensional images of CTA results for stenosis, and estimating their severity using a traditional diameter stenosis analysis with poor accuracy (this often overestimates or underestimates the severity of stenosis). In order to streamline the evaluation of suspected CHD patients, we propose to create a more accurate and consistent diagnostic method of interpreting CTA results. Our approach combines CTA results, cutting-edge 3D printing technology (to create physical models of coronary arteries), and Fractional Flow Reserve (FFR) measurement with pressure sensor (to analyse blood flow in coronary arteries). This project is a preliminary investigation that will involve CT scan coronaries, converted in STL files for 3D printing. The 3D printed coronaries will be rigid and hollow. This complex geometry will be instrumented in a pulsatile flow test rig that simulates the pumping of the heart. The outcome of this investigation is a proof of concept of flow measurements such as pressure drop can be measured in an in-vitro physiological environment.
Project Code: MAE-16509
Diploma in Bioengineering (DBEN)
Supervisor: Xiong, Fang Li.